We invite you to join us at the 3rd conference of the International Rare Diseases Research Consortium (IRDiRC), which will take place February 8-9, 2017 in Paris, France at the conference center of Université Pierre et Marie Curie (UPMC) Jussieu.
E-Rare-3 Call for proposals 2017: Transnational Research Projects for Innovative Therapeutic Approaches for Rare Diseases
The ninth E-Rare joint call for funding multilateral research projects on rare diseases (JTC2017) will be open on the December 5th 2016. The following 17 countries intend to participate in this call: Austria, Belgium, Canada (including Quebec), Finland, France, Germany, Greece, Hungary, Israel, Italy, Japan, Latvia, Poland, Romania, Spain, Switzerland and Turkey.
The aim of the call is to enable scientists in different countries to build an effective collaboration on a common interdisciplinary research project based on complementarities and sharing of expertise, with a clear translational research approach. Projects shall involve a group of rare diseases or a single rare disease following the European definition i.e. a disease affecting not more than five in 10.000 persons in the European Community, EC associated states and Canada.
The specific objective of this call is to promote research projects focusing on the pre-clinical development of therapeutic approaches in suitable existing animal or cell models.
Therapeutic approaches can include:
Cell-based therapy (e.g. somatic cell therapy, cell-based regenerative medicine, tissue engineering, therapies based on combination of cells with scaffolds or substrates, etc.);
Gene therapy (e.g. transfer of nucleic acids for therapeutic purposes including DNA, RNA, oligonucleotides, etc.);
Pharmacological therapy (e.g. use of chemicals or biopharmaceuticals including repurposing approaches, high throughput screening of molecules, etc.).
Project proposals must clearly demonstrate the potential health impact as well as the added-value of transnational collaboration: gathering a critical mass of patients/biological material, sharing of resources (models, databases, diagnosis etc.), harmonization of data, sharing of specific know-how and/or innovative technologies, etc.
Each transnational collaborative project should represent the critical mass to achieve ambitious scientific goals. Consortia are encouraged to demonstrate engagement with industry for its active participation including areas of collaboration, sharing of resources, capabilities and expertise, in order to ensure an efficient transfer of pre-clinical results into clinical utility. Likewise, patient organizations are invited to participate where appropriate as their engagement has the potential to provide new insights that could lead to innovative discoveries, and ensures that research is relevant to patients' concerns.
It is expected that the inclusion of partner groups from participating underrepresented countries will contribute to strengthening the research capacity building in Europe as a whole. Applicants are encouraged to include partners from the participating Eastern European countries (Hungary, Latvia, Poland, Romania, and Turkey). If they include such partners, the maximum number of partners can be increased to seven or eight (instead of six).
The use of existing European health research infrastructures or initiatives is strongly encouraged when appropriate. The following European Research Infrastructures or Initiatives were identified as potentially useful for this kind of study: BBMRI; EATRIS; ECRIN; ELIXIR; EU-OPENSCREEN; INFRAFRONTIER; RD-Connect and European Medicines Agency.
The following approaches are excluded:
Therapeutic approaches concerning rare infectious diseases, rare cancers and rare adverse drug events in treatments of common diseases;
Interventional clinical trials or any other interventional treatment of patients within the project (e.g. compassionate use)
The set-up of new patient registries/databases
Development of new cell or animal models. The relevant cell or animal model must be already established for the purpose of the project;
Surgery or radiation therapies.
Submission and evaluation of projects will be carried out in two stages and integrated with other countries. Each country shall fund its national teams according to its own procedures.
Opening of the call is foreseen for December 5, 2016
The indicative deadline for pre-proposal submission is February 1, 2017.
The indicative deadline for proposal submission is June 2nd, 2017.
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