Funding transnational collaborative research through joint transnational calls is one of the major objectives of E-Rare. This is the most important and effective joint activity to enhance the cooperation between European scientists working on rare diseases and thus reducing the fragmentation of research in this field. E-Rare launches calls on a yearly basis. The topic and eligibility criteria are specified every year and therefore may vary from one call to the other.

The Netherlands
Single cell-based ultra high-resolution characterization of intrathecal immunity in Autoimmune Encephalitis

Project Coordinator

Westfälische Wilhelms-University Münster


Maarten Titulaer University Medical Centre Rotterdam, the Netherlands
Frank Leypoldt Christian-Albrechts-University Kiel Kiel, Germany
Ido Amit Weizmann Institute of Science Rechovot, Israel

In this proposal we aim to study why and how the immune system that is actually meant to protect us from infections and cancer can erroneously attack nerve cells in the brain. The condition is named autoimmune encephalitis (AIE) and can cause – among others – progressive memory loss, mood disturbance and seizures. We previously found genes that make some people more likely to develop the disease. We believe that it is now important to understand how exactly immune cells in AIE are different from healthy persons. We are a group of researchers treating and studying many affected patients and we have a lot of material from patients available to start our study. We have also developed new technologies that give us very detailed information about the immune cells from AIE patients. Especially, these technologies tell us exactly how immune cells react when they are in direct contact with the brain. This combination of having many rare samples and new technologies makes us especially well equipped to undertake the present study. In the future we hope to improve diagnosis and treatment of AIE with our work.  


E-Rare 2012 - Created by Toussaint Biger